Bioengineered self-seeding heart valves
نویسندگان
چکیده
منابع مشابه
Tissue engineering of heart valves--human endothelial cell seeding of detergent acellularized porcine valves.
OBJECTIVE Tissue engineering of heart valves represents a new experimental concept to improve current modes of therapy in valvular heart disease. Drawbacks of glutaraldehyde fixed tissue valves or mechanical valves include the short durability or the need for life-long anticoagulation, respectively. Both have in common the inability to grow, which makes valvular heart disease especially problem...
متن کاملEndothelial progenitor cells as a sole source for ex vivo seeding of tissue-engineered heart valves.
PURPOSES We investigated whether circulating endothelial progenitor cells (EPCs) can be used as a cell source for the creation of a tissue-engineered heart valve (TEHV). METHODS Trileaflet valved conduits were fabricated using nonwoven polyglycolic acid/poly-4-hydroxybutyrate polymer. Ovine peripheral blood EPCs were dynamically seeded onto a valved conduit and incubated for 7, 14, and 21 day...
متن کاملSelf-seeding in cancer.
Despite significant progress in our understanding and treatment of metastatic cancer, nearly all metastatic cancers are incurable. In this Review, we use breast cancer as a model to highlight the limitations and inconsistencies of our existing treatment paradigms for metastatic disease. In turn, we offer a new theory of metastasis, termed "self-seeding. " The self-seeding paradigm, well validat...
متن کاملPreface: Heart valves.
Reference to this organ, which perhaps was not commonplace in the scientific literature 15 years ago, has become exceedingly prevalent in the past 5 years. The field of heart valve research has become contemporary due to a heightened awareness of the seriousness and frequency of heart valve disease. Indeed, valve therapies are still extremely limited for patients above the age of 75 or less tha...
متن کاملTissue-engineered heart valves.
Currently-used mechanical and biological heart valve prostheses have several disadvantages. Mechanical prostheses, based on carbon, metallic and polymeric components, require permanent anticoagulation treatment, and their usage often leads to adverse reactions, e.g. thromboembolic complications and endocarditis. Xenogenous and allogenous biological prostheses are associated with immune reaction...
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ژورنال
عنوان ژورنال: The Journal of Thoracic and Cardiovascular Surgery
سال: 2012
ISSN: 0022-5223
DOI: 10.1016/j.jtcvs.2011.10.005